This study aimed to examine the influence of Industrial Work Practice, Discipline, and Vocational Interest on students’ work readiness in the Motorcycle Engineering Department at SMK Negeri 2 Palembang. This research employed a quantitative correlational design involving 72 twelfth-grade students selected using saturated sampling. Data were collected through Likert-scale questionnaires and analyzed using descriptive statistics, Pearson correlation, simple regression, and multiple linear regression with IBM SPSS 25. The results showed that Industrial Work Practice had a positive and significant effect on work readiness (R² = 0.171; p < 0.05), Discipline demonstrated the strongest influence (R² = 0.390; p < 0.05), and Vocational Interest also significantly affected work readiness (R² = 0.122; p < 0.05). Simultaneously, the three variables contributed 59.2% to students’ work readiness. These findings indicate that practical industrial experience, strong discipline, and vocational interest are important factors in improving vocational students’ readiness to enter the workforce.