This study examines the relationship between industrial work practice experience, career guidance, and vocational interest and students’ work readiness at SMK Negeri 1 Sutera. Work readiness was operationalized as a multidimensional construct including technical competence, work attitude, and adaptability. A quantitative correlational design was employed with a sample of 130 students selected using proportional random sampling. Data were collected through validated questionnaires adapted from previous studies, with acceptable validity (r > 0.30) and reliability (Cronbach’s alpha > 0.70). Data were analyzed using multiple regression after meeting assumptions of normality, linearity, and multicollinearity. The results show that vocational interest has the strongest association with work readiness (β = 0.606, p < 0.001), followed by industrial work practice (β = 0.418, p < 0.001) and career guidance (β = 0.363, p < 0.01). Simultaneously, the three variables explain 31.4% of the variance in work readiness. These findings suggest that both experiential learning and intrinsic motivation are important factors, although other variables beyond this model also contribute to students’ work readiness.